THE EVALUATION OF THE EFFECT OF THE TREATMENTS ON OXIDATIVE STRESS AND INFLAMMATION IN PATIENTS RECEIVING DIFFERENT DIALYSIS MODALITIES

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Koyuncu S., Sipahioğlu H., Koçyiğit İ., Oymak O., Tokgöz B., Sipahioğlu M. H.

JOURNAL OF CONTEMPORARY MEDICINE, vol.13, no.4, pp.580-585, 2023 (TRDizin)

• Publication Type: Article / Article
• Volume: 13 Issue: 4
• Publication Date: 2023
• Doi Number: 10.16899/jcm.1257359
• Journal Name: JOURNAL OF CONTEMPORARY MEDICINE
• Journal Indexes: Directory of Open Access Journals, TR DİZİN (ULAKBİM)
• Page Numbers: pp.580-585
• Erciyes University Affiliated: Yes

Abstract

ABSTRACT Aim: To evaluate the effects of different dialysis methods on oxidative stress and inflammation in patients with end-stage renal disease (ESRD) who are newly enrolled in a routine dialysis program. Material and Methods: In this prospective study, 138 ESRD patients and 30 healthy volunteers were evaluated. Fifty-four of 73 hemodialysis (HD) patients and 51 of 65 periton dialysis (PD) patients completed the study. Other patients were excluded from the study. The levels of superoxide dismutase (SOD) and total antioxidant capacity (TAC) were measured to determine the oxidative stress status, and IL-6, IL-10, and F2 isoprostane levels were measured to determine the inflammation status, just before the start of dialysis treatment and at 6 months. Results: At the beginning of the study, hs-CRP and IL-6 levels were significantly higher in the patient group compared to the control group (p