Variants in TNF and NOS3 (eNOS) genes associated with sepsis in adult patients

ÖZKAN M., GÜNAY N., ŞENER E. F., Karcioglu O., Tahtasakal R., Dal F., ...More

JOURNAL OF GENE MEDICINE, vol.23, no.4, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.1002/jgm.3323
  • Journal Name: JOURNAL OF GENE MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, EMBASE, MEDLINE
  • Keywords: endothelial nitric oxide synthase, polymorphism, sepsis, susceptibility, tumor necrosis factor, TUMOR-NECROSIS-FACTOR, NITRIC-OXIDE SYNTHASE, FACTOR-ALPHA PROMOTER, CORONARY-ARTERY-DISEASE, SEPTIC SHOCK, GLU298ASP POLYMORPHISM, HEMODIALYSIS-PATIENTS, ORGAN DYSFUNCTION, CLINICAL-COURSE, GREATER-THAN
  • Erciyes University Affiliated: Yes

Abstract

Background Sepsis is a life-threatening condition caused by a dysregulated host response to infections and is a leading cause of death in hospitalized patients. The present study aimed to elucidate the possible association between sepsis and the tumor necrosis factor (TNF) gene -308G/A (rs1800629) polymorphism, as well as endothelial nitric oxide synthase (eNOS, NOS3) gene -786T/C (rs2070744), 4a/4b (27 bp-VNTR in intron 4, rs61722009) and 894G/T (Glu298Asp, rs1799983) polymorphisms.