Variants in TNF and NOS3 (eNOS) genes associated with sepsis in adult patients
JOURNAL OF GENE MEDICINE, cilt.23, sa.4, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 4
- Basım Tarihi: 2021
- Doi Numarası: 10.1002/jgm.3323
- Dergi Adı: JOURNAL OF GENE MEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, EMBASE, MEDLINE
- Anahtar Kelimeler: endothelial nitric oxide synthase, polymorphism, sepsis, susceptibility, tumor necrosis factor
- Erciyes Üniversitesi Adresli: Evet
Özet
Background Sepsis is a life-threatening condition caused by a dysregulated host response to infections and is a leading cause of death in hospitalized patients. The present study aimed to elucidate the possible association between sepsis and the tumor necrosis factor (TNF) gene -308G/A (rs1800629) polymorphism, as well as endothelial nitric oxide synthase (eNOS, NOS3) gene -786T/C (rs2070744), 4a/4b (27 bp-VNTR in intron 4, rs61722009) and 894G/T (Glu298Asp, rs1799983) polymorphisms.