Variants in TNF and NOS3 (eNOS) genes associated with sepsis in adult patients


ÖZKAN M. , GÜNAY N. , ŞENER E. F. , Karcioglu O., Tahtasakal R., Dal F., ...More

JOURNAL OF GENE MEDICINE, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2021
  • Doi Number: 10.1002/jgm.3323
  • Title of Journal : JOURNAL OF GENE MEDICINE

Abstract

Background Sepsis is a life-threatening condition caused by a dysregulated host response to infections and is a leading cause of death in hospitalized patients. The present study aimed to elucidate the possible association between sepsis and the tumor necrosis factor (TNF) gene -308G/A (rs1800629) polymorphism, as well as endothelial nitric oxide synthase (eNOS, NOS3) gene -786T/C (rs2070744), 4a/4b (27 bp-VNTR in intron 4, rs61722009) and 894G/T (Glu298Asp, rs1799983) polymorphisms.