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ÖZKAN M., GÜNAY N., ŞENER E. F., Karcioglu O., Tahtasakal R., Dal F., ...More
JOURNAL OF GENE MEDICINE, vol.23, no.4, 2021 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
23
Issue:
4
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Publication Date:
2021
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Doi Number:
10.1002/jgm.3323
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Journal Name:
JOURNAL OF GENE MEDICINE
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, EMBASE, MEDLINE
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Keywords:
endothelial nitric oxide synthase, polymorphism, sepsis, susceptibility, tumor necrosis factor, TUMOR-NECROSIS-FACTOR, NITRIC-OXIDE SYNTHASE, FACTOR-ALPHA PROMOTER, CORONARY-ARTERY-DISEASE, SEPTIC SHOCK, GLU298ASP POLYMORPHISM, HEMODIALYSIS-PATIENTS, ORGAN DYSFUNCTION, CLINICAL-COURSE, GREATER-THAN
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Erciyes University Affiliated:
Yes
Abstract
Background Sepsis is a life-threatening condition caused by a dysregulated host response to infections and is a leading cause of death in hospitalized patients. The present study aimed to elucidate the possible association between sepsis and the tumor necrosis factor (TNF) gene -308G/A (rs1800629) polymorphism, as well as endothelial nitric oxide synthase (eNOS, NOS3) gene -786T/C (rs2070744), 4a/4b (27 bp-VNTR in intron 4, rs61722009) and 894G/T (Glu298Asp, rs1799983) polymorphisms.