JOURNAL OF GENE MEDICINE, 2021 (Journal Indexed in SCI)
Article / Article
Title of Journal :
JOURNAL OF GENE MEDICINE
endothelial nitric oxide synthase, polymorphism, sepsis, susceptibility, tumor necrosis factor, TUMOR-NECROSIS-FACTOR, NITRIC-OXIDE SYNTHASE, FACTOR-ALPHA PROMOTER, CORONARY-ARTERY-DISEASE, SEPTIC SHOCK, GLU298ASP POLYMORPHISM, HEMODIALYSIS-PATIENTS, ORGAN DYSFUNCTION, CLINICAL-COURSE, GREATER-THAN
Background Sepsis is a life-threatening condition caused by a dysregulated host response to infections and is a leading cause of death in hospitalized patients. The present study aimed to elucidate the possible association between sepsis and the tumor necrosis factor (TNF) gene -308G/A (rs1800629) polymorphism, as well as endothelial nitric oxide synthase (eNOS, NOS3) gene -786T/C (rs2070744), 4a/4b (27 bp-VNTR in intron 4, rs61722009) and 894G/T (Glu298Asp, rs1799983) polymorphisms.