The effects of ozone therapy on caspase pathways, TNF-alpha, and HIF-1 alpha in diabetic nephropathy

Guclu, Aydin; Erken, Haydar; Erken, Gulten; Dodurga, Yavuz; Yay, ARZU; Ozcoban, ÖZGE; Simsek, Hasan; Akcilar, Aydin; Kocak, Fatma

doi:10.1007/s11255-015-1169-8

The effects of ozone therapy on caspase pathways, TNF-alpha, and HIF-1 alpha in diabetic nephropathy

Guclu A., Erken H. A., Erken G., Dodurga Y., Yay A. H., Ozcoban Ö., ...Daha Fazla

INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.48, sa.3, ss.441-450, 2016 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 48 Sayı: 3
Basım Tarihi: 2016
Doi Numarası: 10.1007/s11255-015-1169-8
Dergi Adı: INTERNATIONAL UROLOGY AND NEPHROLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.441-450
Anahtar Kelimeler: Diabetic nephropathy, Ozone therapy, Caspase, HIF-1 alpha, TNF-alpha
Erciyes Üniversitesi Adresli: Evet

Özet

Accelerated apoptosis plays a vital role in the development of diabetic vascular complications. Ozone may attenuate diabetic nephropathy by means of decreased apoptosis-related genes. The aim of our study was to investigate the effect of ozone therapy on streptozotocin-induced diabetic nephropathy in rats. Also the histopathological changes in diabetic kidney tissue with ozone treatment were evaluated.