The effects of ozone therapy on caspase pathways, TNF-alpha, and HIF-1 alpha in diabetic nephropathy

Guclu A., Erken H. A., Erken G., Dodurga Y., Yay A. H., Ozcoban Ö., ...Daha Fazla

INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.48, sa.3, ss.441-450, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s11255-015-1169-8
  • Dergi Adı: INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.441-450
  • Anahtar Kelimeler: Diabetic nephropathy, Ozone therapy, Caspase, HIF-1 alpha, TNF-alpha
  • Erciyes Üniversitesi Adresli: Evet

Özet

Accelerated apoptosis plays a vital role in the development of diabetic vascular complications. Ozone may attenuate diabetic nephropathy by means of decreased apoptosis-related genes. The aim of our study was to investigate the effect of ozone therapy on streptozotocin-induced diabetic nephropathy in rats. Also the histopathological changes in diabetic kidney tissue with ozone treatment were evaluated.