The effects of ozone therapy on caspase pathways, TNF-alpha, and HIF-1 alpha in diabetic nephropathy

Guclu, Aydin; Erken, Haydar; Erken, Gulten; Dodurga, Yavuz; Yay, ARZU; Ozcoban, ÖZGE; Simsek, Hasan; Akcilar, Aydin; Kocak, Fatma

doi:10.1007/s11255-015-1169-8

The effects of ozone therapy on caspase pathways, TNF-alpha, and HIF-1 alpha in diabetic nephropathy

Guclu A., Erken H. A. , Erken G., Dodurga Y., Yay A. H. , Ozcoban Ö. , ...More

INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.48, no.3, pp.441-450, 2016 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 48 Issue: 3
Publication Date: 2016
Doi Number: 10.1007/s11255-015-1169-8
Title of Journal : INTERNATIONAL UROLOGY AND NEPHROLOGY
Page Numbers: pp.441-450

Abstract

Accelerated apoptosis plays a vital role in the development of diabetic vascular complications. Ozone may attenuate diabetic nephropathy by means of decreased apoptosis-related genes. The aim of our study was to investigate the effect of ozone therapy on streptozotocin-induced diabetic nephropathy in rats. Also the histopathological changes in diabetic kidney tissue with ozone treatment were evaluated.