Prevention of Burn Wound Progression by Mesenchymal Stem Cell Transplantation: Deeper Insights Into Underlying Mechanisms

Abbas O. L., Ozatik O., GÖNEN Z. B., Ogut S., Entok E., Ozatik F. Y., ...Daha Fazla

ANNALS OF PLASTIC SURGERY, cilt.81, sa.6, ss.715-724, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 81 Sayı: 6
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1097/sap.0000000000001620
  • Dergi Adı: ANNALS OF PLASTIC SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.715-724
  • Anahtar Kelimeler: angiogenesis, apoptosis, burn, mesenchymal stem cell, oxidative stress, stasis zone, PARTIAL THICKNESS BURNS, OXIDATIVE STRESS, FREE-RADICALS, INJURY, APOPTOSIS, DEATH, SKIN, ZONE, REGENERATION, NECROSIS
  • Erciyes Üniversitesi Adresli: Evet

Özet

Introduction Burns are dynamic wounds that may present a progressive expansion of necrosis into the initially viable zone of stasis. Therefore, salvage of this zone is a major subject of focus in burn research. The beneficial effects of mesenchymal stem cells (MSCs) on the survival of the zone of stasis have been previously documented. However, many gaps still exist in our knowledge regarding the underlying protective mechanisms. Hence, this study was designed to evaluate the pathophysiological basis of MSCs in the prevention of burn wound progression.