Prevention of Burn Wound Progression by Mesenchymal Stem Cell Transplantation: Deeper Insights Into Underlying Mechanisms


Abbas O. L. , Ozatik O., GÖNEN Z. B. , Ogut S., Entok E., Ozatik F. Y. , ...Daha Fazla

ANNALS OF PLASTIC SURGERY, cilt.81, ss.715-724, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 81 Konu: 6
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1097/sap.0000000000001620
  • Dergi Adı: ANNALS OF PLASTIC SURGERY
  • Sayfa Sayıları: ss.715-724

Özet

Introduction Burns are dynamic wounds that may present a progressive expansion of necrosis into the initially viable zone of stasis. Therefore, salvage of this zone is a major subject of focus in burn research. The beneficial effects of mesenchymal stem cells (MSCs) on the survival of the zone of stasis have been previously documented. However, many gaps still exist in our knowledge regarding the underlying protective mechanisms. Hence, this study was designed to evaluate the pathophysiological basis of MSCs in the prevention of burn wound progression.