The Behavior of (cyclic-alkylidene)hydrazinecarbothioamides in Cyclization with Dimethyl acetylenedicarboxylate


Hassan A. A. , Mohamed S. K. , Mohamed N. K. , El-Shaieb K. M. A. , Abdel-Aziz A. T. , Mague J. T. , ...Daha Fazla

JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.54, ss.2043-2053, 2017 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 54 Konu: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1002/jhet.2803
  • Dergi Adı: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Sayfa Sayıları: ss.2043-2053

Özet

A series of (Z)-methyl 2(Z)-3-substituted-2-(cycloalkylidenehydrazono)-4-oxothiazolidin-5-ylidene)-acetate derivatives were synthesized via condensation alkylidene-N-substituted hydrazinecarbothioamides with dimethyl acetylenedicarboxylate. The synthesized compounds were characterized by using different spectroscopic methods and confirmed by single crystal X-ray analysis. The behavior of (cyclic-alkylidene) hydrazinecarbothioamides in cyclization was presented. The mechanism of transformation of (Z)-methyl 2-((Z)-3-(cyclopentylideneamino)-4-oxo-2-(phenylimino)thiazolidin-5-ylidene)acetate (14) into the more stable (Z)-Methyl 2-[(Z)-2-(cyclopentylidenehydrazono)-4-oxo-3-phenylthiazolidin-5-ylidene]acetate (5a) was discussed and confirmed.