The alpha-2 receptor agonist dexmedetomidine attenuates vancomycin-induced acute kidney injury

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Bayram A., Erkan G. N., Talih G., Başkol G., Deniz K., Yıldız K., ...Daha Fazla

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.120, sa.6, ss.429-433, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 120 Sayı: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.4149/bll_2019_069
  • Dergi Adı: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.429-433
  • Anahtar Kelimeler: dexmedetomidine, nephrotoxicity, rat, vancomycin, vasoconstriction, vasodilation, TARGETING SUPEROXIDE-DISMUTASE, PROXIMAL TUBULE CELLS, INDUCED NEPHROTOXICITY, NITRIC-OXIDE, TROUGH CONCENTRATIONS, OXIDATIVE STRESS, ANTIOXIDANTS, AMRINONE
  • Erciyes Üniversitesi Adresli: Evet

Özet

OBJECTIVE: This study was conducted to evaluate the protective effect of dexmedetomidine on nephrotoxicity and the mechanism of renoprotection following vancomycin-induced nephrotoxicity in rats. METHODS: Thirty-two albino Wistar rats were divided into four groups. The control group received intraperitoneal (IP) physiological saline solution, the vancomycin (VMC) group received IP 200 mg/kg vancomycin, the dexmedetomidine (DEX) group received IP 5 μg/kg dexmedetomidine, and the vancomycin and dexmedetomidine (VMC+DEX) group received IP 200 mg/kg vancomycin followed by IP 5 μg/kg dexmedetomidine 20 min after the vancomycin injection. On the 8th day of the experiment, histopathological and biochemical parameters were assessed. RESULTS: Creatinine levels were signifi cantly higher in VMC and VMC+DEX groups. The endothelin-1 level was signifi cantly higher in VMC group. Nitric oxide levels were statistically lower in VMC and VMC+DEX groups. Histopathologic assessments revealed that the extent of renal damage was signifi cantly higher in group VMC (n = 4 with damage of Grade 3) compared to group VMC+DEX (n = 0 with damage of Grade 3). CONCLUSION: It was determined that dexmedetomidine can reduce the extent of renal damage by preventing the elevation of vasoconstrictor agents (Tab. 2, Fig. 1, Ref. 36).