Investigation of oral selegiline and rasagiline administration on QT interval in conscious rabbits
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.13, no.2, pp.95-98, 2009 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 13 Issue: 2
- Publication Date: 2009
- Journal Name: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.95-98
- Keywords: Rasagilin, Selegiline, ECG, QT, Rabbit
- Erciyes University Affiliated: No
Abstract
Rasagiline (RSG) and selegiline (SEL) are potent selective monoamine oxidase-B inhibitors and used in the treatment of Parkinson's disease. Selegiline is metabolized in vivo to I-methamphetamine and I-amphetamine which effect cardiovascular system. Therefore, the aim of this study was to evaluate and to compare the effects of long-term use of these drugs on QT interval in conscious rabbits.