Carnitine Supplementation Modulates High Dietary Copper-Induced Oxidative Toxicity and Reduced Performance in Laying Hens


Guclu B. , KARA K. , Cakir L. , ÇETİN E. , KANBUR M.

BIOLOGICAL TRACE ELEMENT RESEARCH, vol.144, pp.725-735, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 144
  • Publication Date: 2011
  • Doi Number: 10.1007/s12011-011-9122-x
  • Title of Journal : BIOLOGICAL TRACE ELEMENT RESEARCH
  • Page Numbers: pp.725-735
  • Keywords: Biochemical parameter, Carnitine, Copper toxicity, Egg quality, Laying hen, Performance, LIPID-PEROXIDATION, TISSUE ACCUMULATION, ANTIOXIDANT, STRESS, EGG, BIOAVAILABILITY, PARAMETERS, GRAVITY, DAMAGE, BRAIN

Abstract

This experiment was conducted to evaluate the effects of l-carnitine on performance, egg quality and certain biochemical parameters in laying hens fed a diet containing high levels of copper proteinate. Forty-eight 42-week-old laying hens were divided into four groups with four replicates. The laying hens were fed with a basal diet (control) or the basal diet supplemented with either 400 mg carnitine (Car)/kg diet, 800 mg copper proteinate (CuP)/kg diet or 400 mg carnitine + 800 mg copper (Car+CuP)/kg diet, for 6 weeks. Supplemental CuP decreased feed consumption (p < 0.01), feed efficiency and egg production (p < 0.001), as compared to control. The combination of Car and CuP increased (p < 0.001) egg production and feed efficiency as compared to CuP. The activities of alanine aminotransferase (p < 0.05) and alkaline phosphatase (p < 0.01) were increased, while lactate dehydrogenase activity was decreased (p < 0.001) by supplemental CuP and Car+CuP. Supplemental CuP caused an increase in plasma malondialdehyde (p < 0.01) and nitric oxide levels (p < 0.05). In the Car+CuP group, this increase was observed to have been reduced significantly (p < 0.05). Furthermore, Car+CuP increased (p < 0.05) glucose level. These results indicate that the carnitine and copper combination may prevent the possible adverse effects of high dietary copper on performance and lipid peroxidation in hens.