Prophylactic Central Nervous System Irradiation Is Not Indispensable in Adult Patients with Acute Lymphoblastic Leukemia: A Multicenter Retrospective Cohort Study

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ÇINAR O. E., GÖKER H., FİDAN K., Aydin O., Pashayev T., MALKAN Ü. Y., ...Daha Fazla

TURKISH JOURNAL OF HEMATOLOGY, cilt.39, sa.3, ss.152-159, 2022 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.4274/tjh.galenos.2022.2021.0680
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.152-159
  • Anahtar Kelimeler: Craniospinal, Young adults, Radiation toxicity, Central nervous system relapse, Acute lymphoblastic leukemia, CHILDRENS CANCER GROUP, LIPOSOMAL CYTARABINE, RISK GROUPS, DIAGNOSIS, THERAPY, RELAPSE, CNS, CHEMOTHERAPY, METHOTREXATE, INVOLVEMENT
  • Erciyes Üniversitesi Adresli: Evet

Özet

Objective: Studies comparing the efficacy and safety of prophylactic regimens for central nervous system (CNS) involvement in acute lymphoblastic leukemia (ALL) are scarce in adults. This multicenter retrospective study aimed to compare the efficacy of prophylactic regimens with and without CNS irradiation on the development of CNS relapse during follow-up. Materials and