In this study, novel water, oil and stain repellent chemicals such as polymeric dendrimer containing fluorocarbon, nano sized fluorocarbon polymer, nano-silica acid and conventional agents such as paraffin emulsion containing zirconium salt and conventional FC (micro emulsion) compound were applied to cotton fabrics. After treatments, the water, oil and stain repellency, air permeability and water vapour permeability of all the fabrics treated were tested, and the effect of the chemical concentration, performance and washing resistance of all the chemicals were compared. In general, the water, oil and stain repellency results showed that new chemicals such as polymeric dendrimer containing FC and FC nanomolecules had better results than conventional ones in terms of performance and washing resistance. The performance of all the chemicals increased with a rise in chemical concentration. The air and water vapour permeability of all the fabrics treated were not negatively affected. FTIR analyses of the fabrics treated were also carried out.