This study was carried out in order to determine knowledge and attitudes of emergency nurses about Crimean-Congo haemorrhagic Fever. This descriptive research was carried out where the disease is frequent, in six cities in Turkey. One hundred forty-three nurses who worked in the emergency room were recruited to the study. Data were collected with a questionnaire form and were analysed by chi-squared test. The mean age of the nurses was 31.0 +/- 5.7 years. It was determined that 68.8% of the nurses claimed to have sufficient knowledge about the disease, 99.3% said that it was a virus that caused the disease, and 94.3% said that health-care personnel exposed to it were under great risk. It was concluded that most of the nurses had relatively good knowledge about the disease and that they did not want to run the high risk of infection and mortality by treating patients who had the disease.