Nowadays, the problem of wear in the knee and hip joints is an important issue that concerns many people and still requires new solutions. In recent years, researchers dealing with knee and hip articular cartilage erosion continue to investigate the subject in terms of biotribology. In this study, recent developments and studies in this relevant area are been examined. By using the basic principles of tribology, useful new methods that can be used in the field of biotribology can be produced. Artificial joints designed using various materials such as metals, ceramics, polymers and composites are still being studied. New studies in this area will affect the development of implant technology. Different alloys or composites are currently being tested for new implant designs. Moving implants with a risk of wear are tested in laboratory conditions in simulator devices before they are used in the human body. Major topics such as nanotechnology, tissue engineering, orthopedics, tribology, biotribology, lubrication, organ transplantation and artificial organs, which are still important today, will be useful in the search for finding suitable solutions in the future in biotribological studies. This review article aims to provide an overview of in-vitro studies at the theoretical and laboratory conditions that must be performed prior to clinical investigation.