Anti-tubercular Activity of Ruthenium (II) Complexes with Polypyridines

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Hadda T. B., AKKURT M., Baba M. F., Daoudi M., Bennani B., Kerbal A., ...More

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.24, no.2, pp.457-463, 2009 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 24 Issue: 2
• Publication Date: 2009
• Doi Number: 10.1080/14756360802188628
• Journal Name: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.457-463
• Erciyes University Affiliated: Yes

Abstract

A series of nine polypyridyl-ruthenium (II) complexes (N-ligands=2,2'-bipyridines; 2,2'-6',2'-terpyridines, di-alkyloxy-2,2'-6,2-bipyridine-3,3'-di-carboxylates), were tested against Mycobacterium tuberculosis (MBT). The complex (11) showed remarkable activity against MBT as compared to other complexes, (1-10). The aquo ligand of complex (11), as opposed to other chloro and acetonitrile derivatives, appears to play a key role in the antitubercular potency of this new class of metal-based compounds.