The effect of propylthiouracil on plasma adenosine deaminase activity in patients with psoriasis Psoriazisli hastalarda, propiltiourasil'in plazma adenozin deaminaz aktivitesi uzerine etkisi


KÖSE S. K. , Utas S., YAZICI C. , Akdas A., Kelestimur F., Dogan P.

Turkderm Deri Hastaliklari ve Frengi Arsivi, vol.32, no.2, pp.111-115, 1998 (Journal Indexed in SCI Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 2
  • Publication Date: 1998
  • Title of Journal : Turkderm Deri Hastaliklari ve Frengi Arsivi
  • Page Numbers: pp.111-115

Abstract

Background and Design: The point of view that T lymphocyte activation may be correlated to the pathogenesis of psoriasis has been considered important during last years. Adenosine deaminase (ADA) activity has been accepted as a nonspecific marker for the activation of T cells. In this study, the presence of T cell activation and also the effectiveness of propylthiouracil (PTU), suggested as an antioxidant ammunomodulatory, for therapeutic purpose were investigated in psoriasis. Materials and Methods: ADA activity was measured in the plasma of 30 psoriatic patients resistant to conventional therapy and compared with that of healthy control subjects (n:15). Thereafter, plasma ADA activity was measured again in 16 of those patients orally administrated PTU (3x100 mg/day) for two months. The severity of the disease was evaluated in the pre- and post-treatment cases according to PASI scores. Results: Plasma ADA activity was found to be higher in those patients (20.66±5.88 U/L) than that of controls (16.68±3.32 U/L). It was observed that plasma ADA activity (21.34±5.89 U/L) was lowered after PTU treatment (15.56±3.31 U/L). PASI scores of patients were found to be lower after PTU treatment. Conclusion: It may be suggested that T lymphocyte activation may play an important role in the pathogenesis of psoriasis, and also PTU may be effective on the supression of T cell activation and therefore on the achievement of clinical improvement in psoriasis.