Akademik Veri Yönetim Sistemi
Clinical Psychopharmacology and Neuroscience, cilt.24, sa.1, ss.58-66, 2026 (SCI-Expanded, Scopus)
Objective: Attention-deficit/hyperactivity disorder is one of the most common psychiatric disorders in childhood. This study aims to examine blood levels of glial cell line-derived neurotrophic factor and neuron-specific enolase in children with attention-deficit/hyperactivity disorder, and to explore their relationships with sleep patterns, eating behaviors, and attention-deficit/hyperactivity disorder symptoms. Methods: A total of 51 patients diagnosed with attention-deficit/hyperactivity disorder and 20 healthy controls were included in the study. The Children’s Sleep Habits Questionnaire and Eating Behavior Assessment Scale for Children were administered. Glial cell line-derived neurotrophic factor and neuron-specific enolase levels were measured using the Bioassay Technology Laboratory Human ELISA Kit. Results: When comparing the serum glial cell line-derived neurotrophic factor levels between groups, no statistically significant difference was found in the distribution of glial cell line-derived neurotrophic factor levels (p = 0.645). The serum neuron-specific enolase levels in the attention-deficit/hyperactivity disorder group were found to be higher than the control group (p = 0.038). Correlation analysis demonstrated a negative correlation between glial cell line-derived neurotrophic factor levels and total scores on the eating scale (r = −0.309, p = 0.026). Conclusion: These results highlight the possible involvement of glial cell line-derived neurotrophic factor in the regulation of eating patterns among children diagnosed with attention-deficit/hyperactivity disorder. Higher serum neuron-specific enolase levels were observed as discriminative between healthy and attention-deficit/hyperactivity disorder children.