Combined imaging with Ga-68-DOTA-TATE and F-18-FDG PET/CT on the basis of volumetric parameters in neuroendocrine tumors

Creative Commons License

ABDÜLREZZAK Ü., KURT Y. K., KULA M., TUTUŞ A.

NUCLEAR MEDICINE COMMUNICATIONS, cilt.37, sa.8, ss.874-881, 2016 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 8
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1097/mnm.0000000000000522
  • Dergi Adı: NUCLEAR MEDICINE COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.874-881
  • Anahtar Kelimeler: F-18-FDG PET, CT, Ga-68-DOTA-TATE PET, CT, neuroendocrine tumor, volumetric analysis, STANDARDIZED UPTAKE VALUES, LYMPH-NODE STATUS, FDG PET/CT, PROGNOSTIC VALUE, PREDICTIVE-VALUE, ROI DEFINITION, SURVIVAL, CANCER, RECONSTRUCTION, THERAPY
  • Erciyes Üniversitesi Adresli: Evet

Özet

AimTo assess the additional contribution of the combined imaging approach with Ga-68-DOTA-TATE and fluorine-18 fluorodeoxyglucose (F-18-FDG) on the basis of volumetric parameters in neuroendocrine tumors (NETs).Materials and methodsForty-one patients with NET (19 women, 22 men; age range: 30-79 years; mean age: 56.712.3 years) underwent Ga-68 DOTA-TATE and F-18-FDG PET/computed tomography (CT) imaging. Within the drawn regions of interest, in addition to evaluating the maximum and mean standardized uptake values (SUVmax and SUVmean), the metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in F-18-FDG PET/CT imaging, and the somatostatin receptor density and total lesion somatostatin receptor expression (TLSRE) in Ga-68 somatostatin receptor imaging (SRI) were measured. The patients were graded on the basis of the proliferation index: well (G1; Ki-67 2), moderately (G2; Ki-67=3-20), and poorly (G3; Ki-67>20) differentiated groups.ResultsOf the 41 NET patients, 22, 14, and five were in the G1 (53.7%), G2 (34.1%), and G3 (12.2%) groups, respectively. Liver metastases had significantly higher TLSRE values than the TLG values. Ki-67 levels showed a positive correlation with the primary tumor MTV and TLG values. Cg-A levels had a positive correlation with the volumetric parameters of the whole-body tumor burden (P<0.001).Conclusion(68)Ga SRI and F-18-FDG PET/CT provide complementary information on treatment protocol and response assessment. While assessing the prognosis and tumor aggressiveness, lesions and whole-body tumor burdens can be calculated on the basis of volumetric parameters by F-18-FDG PET/CT using MTV and TLG, and by Ga-68 SRI using somatostatin receptor density and TLSRE.

AIM:

To assess the additional contribution of the combined imaging approach with Ga-DOTA-TATE and fluorine-18 fluorodeoxyglucose (F-FDG) on the basis of volumetric parameters in neuroendocrine tumors (NETs).

MATERIALS AND METHODS:

Forty-one patients with NET (19 women, 22 men; age range: 30-79 years; mean age: 56.7±12.3 years) underwent Ga DOTA-TATE and F-FDG PET/computed tomography (CT) imaging. Within the drawn regions of interest, in addition to evaluating the maximum and mean standardized uptake values (SUVmax and SUVmean), the metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in F-FDG PET/CT imaging, and the somatostatin receptor density and total lesion somatostatin receptor expression (TLSRE) in Ga somatostatin receptor imaging (SRI) were measured. The patients were graded on the basis of the proliferation index: well (G1; Ki-67 ≤2), moderately (G2; Ki-67=3-20), and poorly (G3; Ki-67>20) differentiated groups.

RESULTS:

Of the 41 NET patients, 22, 14, and five were in the G1 (53.7%), G2 (34.1%), and G3 (12.2%) groups, respectively. Liver metastases had significantly higher TLSRE values than the TLG values. Ki-67 levels showed a positive correlation with the primary tumor MTV and TLG values. Cg-A levels had a positive correlation with the volumetric parameters of the whole-body tumor burden (P<0.001).

CONCLUSION:

Ga SRI and F-FDG PET/CT provide complementary information on treatment protocol and response assessment. While assessing the prognosis and tumor aggressiveness, lesions and whole-body tumor burdens can be calculated on the basis of volumetric parameters by F-FDG PET/CT using MTV and TLG, and by Ga SRI using somatostatin receptor density and TLSRE.