Three SNPs in the GSTO1, GST02 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease

Ozturk A., Desai P., Minster R., DeKosky S., Kamboh M.

NEUROBIOLOGY OF AGING, vol.26, no.8, pp.1161-1165, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 8
  • Publication Date: 2005
  • Doi Number: 10.1016/j.neurobiolaging.2004.11.001
  • Journal Name: NEUROBIOLOGY OF AGING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1161-1165
  • Keywords: Alzheimer's disease, chromosome 10, haplotype, age-at-onset, CHOLINE-ACETYLTRANSFERASE GENE, SINGLE NUCLEOTIDE POLYMORPHISM, PLASMINOGEN-ACTIVATOR, GENOME SCREEN, LINKAGE, GENOTYPE, LOCUS, PEDIGREES, 10Q
  • Erciyes University Affiliated: No

Abstract

Linkage studies suggest the presence of putative risk and/or age-at-onset genes for Alzheimer's disease on Chromosome 10. Recently, a genomic converging approach using a combination of linkage, expression and association studies has reported significant associations of the glutathione S-transferase omega 1 and 2 (GSTO1 and GST02) genes and possibly the protease serine 11 (PRSS11) gene on chromosome 10 with age-at-onset, but not risk, for Alzheimer's disease (AD) and Parkinson disease. We investigated the association of the reported three polymorphisms in 990 sporadic late-onset AD cases (26% autopsy confirmed) and 735 controls. In our sample, we found no association either with age-at-onset in AD cases or with disease risk in the case-control cohort. However, haplotype analysis revealed a modest association of one haplotype with AD risk (p = 0.04). Additional markers in these genes need to be screened to explore their role in the etiology of AD. (c) 2004 Elsevier Inc. All rights reserved.