The in vitro susceptibilities of propolis and antifungal drugs were determined against some yeasts isolated from patients with superficial mycoses. The agents tested included fluconazole, itraconazole, ketoconazole, terbinafine and propolis. MICs were determined by the broth microdilution technique following National Committee for Clinical Laboratory Standards document M27-P. For all Candida albicans isolates from the patients with superficial mycoses, ketoconazole presented higher (P < 0.05) efficiency than that of the other antifungal agents tested. The geometric mean MIC values of antifungal drugs and propolis against the yeasts tested ranged from 0.087 to 12.69 mu g/mL and 0.4-0.6 mu g/mL, respectively. Propolis also showed an important antifungal activity against the yeasts tested, MIC ranges of the propolis were between 0.01-1.65 mu g/mL. Based on these results, propolis requires further investigation as a potential agent for the treatment of superficial mycoses.