Research Information System
The 7th Eurasia Congress of Infectious Diseases, Tiflis, Georgia, 30 September - 03 October 2015, vol.241, pp.367
INTRODUCTION: Brucellosis is an important zoonotic disease. It leads a lot of different complications. One of the complications are hematological such as thrombocytopenia, leucopenia, anemia etc. It can be also mixed in with hematological malignancies.
We aimed to document of brucellosis hematological manifestations and complications with the recent multicenter study in Turkey.
METHODS: In this study, adult patients who were diagnosed during January 01, 2004-June 30, 2015 were included retrospectively.
It was adopted as the diagnostic criteria for the diagnosis of brucellosis; in the presence of clinical symptoms compatible with brucellosis, isolation bacteria from blood cultures or as serological (standard tube agglutination ≥1/160). It was based on the cases
to be accompanied. Hematological findings (anemia, thrombocytopenia, neutropenia, pancytopenia, coagulation disorder, etc.) were screened in assessing the hematological involvement of brucellosis and severity degrees of the cases .
RESULTS: In the study 723 cases were included from 21 centers in Turkey. Fever 530 (74.8%), night sweats 445 (65.8%), arthralgia, 549 (77.9%), fatigue 559 (80%), anorexia 408 (60.2%), weight loss 203 (30.4%), splenomegaly 198 (28.2%) and hepatomegaly
in 191 (27.2%) were present in the patients. As hematological complications; isolated anemia 37 (52.14%), isolated leucopenia 31 (4.29%), isolated thrombocytopenia 61 (8.44%), anemia with leucopenia 69 (9.54%), anemia with thrombocytopenia 57 (7.88%),
leucopenia with thrombocytopenia 38 (5.26%) and pancytopenia 90 (12.45%) were observed. Excluding antibiotics, supportive therapies were applied to the patients for anemia 20/593 (3.37%), leucopenia 3/228 (1.31%) and thrombocytopenia 10/246
(4.06%).
CONCLUSION: Brucellosis affects to reticuloendothelial system with or without all other systems. After the detection or suspicion of bone marrow involvement in the patients who suffering such as fever, night sweats, arthralgia, fatigue and anorexia symptoms, the presence of brucellosis should be investigated and tried to be treated at an early stage especially in the endemic regions.