Effect of zinc deficiency on chromosomal abnormalities in mice


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Ozkul Y. , Dursun N., Erenmemisoglu A., Suer C. , Saatci C.

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, cilt.179, ss.247-251, 1996 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 179 Konu: 4
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1620/tjem.179.247
  • Dergi Adı: TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
  • Sayfa Sayıları: ss.247-251

Özet

In the present study we investigated the effect of zinc-deficiency on chromosomal abnormalities and mitotic index, and the interaction of zinc-deficiency and methotrexate. Therefore, two zinc-deficient and two zinc-adequate diet received mouse groups were constituted. Methotrexate was injected to one of zinc-deficient and one of zinc-adequate diet groups. There were no structural and numerical abnormalities in all groups. However, mitotic index was significantly lower than other groups in zinc-deficient and methotrexate administered mice.