Effect of zinc deficiency on chromosomal abnormalities in mice


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Ozkul Y. , Dursun N., Erenmemisoglu A., Suer C. , Saatci C.

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, vol.179, no.4, pp.247-251, 1996 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 179 Issue: 4
  • Publication Date: 1996
  • Doi Number: 10.1620/tjem.179.247
  • Title of Journal : TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
  • Page Numbers: pp.247-251

Abstract

In the present study we investigated the effect of zinc-deficiency on chromosomal abnormalities and mitotic index, and the interaction of zinc-deficiency and methotrexate. Therefore, two zinc-deficient and two zinc-adequate diet received mouse groups were constituted. Methotrexate was injected to one of zinc-deficient and one of zinc-adequate diet groups. There were no structural and numerical abnormalities in all groups. However, mitotic index was significantly lower than other groups in zinc-deficient and methotrexate administered mice.