Characterization of the RNA dependent DNA polymerase of bovine leukemia virus

DEMİRHAN I., Altanerova V., Chandra A., Gerber T., Hofmann D., Altaner C., ...Daha Fazla

ANTICANCER RESEARCH, cilt.16, ss.2501-2505, 1996 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16
  • Basım Tarihi: 1996
  • Dergi Adı: ANTICANCER RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2501-2505
  • Erciyes Üniversitesi Adresli: Hayır

Özet

The reverse transcriptase - RNA dependent DNA polymerase of Bovine Leukemia Virus (BLV) was isolated and characterized. The enzyme has a molecular weight of about 80kd and the isoelectric point is 7.6. The enzyme prefers magnesium, as a divalent cation using synthetic homopolymeric template primer poly (C) oligo (dG). Monoclonal antibodies directed against reverse transcriptase of human immunodeficiency virus type I (HIV-I) did not crossreact with the isolated polymerase.