The effect of serotonin on penicillin-induced epileptiform activity


Taşkıran M., Tasdemır A., Ayyıldız N., Ayyıldız M., Agar E.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.129, sa.7, ss.687-697, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 129 Sayı: 7
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/00207454.2018.1557166
  • Dergi Adı: INTERNATIONAL JOURNAL OF NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.687-697
  • Anahtar Kelimeler: Serotonin, DOI, methysergide, 5-HTP, penicillin-induced epileptiform activity, INDUCED SEIZURES, INDUCED CONVULSIONS, 5-HT2C RECEPTORS, PILOCARPINE MODEL, RAT MODEL, ANTICONVULSANT, FLUOXETINE, EPILEPSY, 5-HYDROXYTRYPTAMINE, INVOLVEMENT
  • Erciyes Üniversitesi Adresli: Evet

Özet

Objective: This study was aimed at examining the epileptiform activity of the 5-HT2 serotonin receptor agonist and antagonist, and 5-hydroxytryptophan (5-HTP) in penicillin-induced epilepsy in albino Wistar rats. Methods: For this purpose, 90 albino male Wistar rats were used in this study. Epileptiform activity was induced by an injection of penicillin, an agonist of GABAA receptor, (500 IU, i.c.) into the somatomotor cortex. Thirty minutes after the injection of penicillin, 2,5-dimethoxy-4-iodoamphetamine (DOI, an agonist of 5-HT2 receptor) (0.5, 1, 2 and 4 mg/kg, i.p.), methysergide, an antagonist of 5-HT2 receptor, (1, 10, 20, 50 and 100 mu M, i.c.v.) and 5-HTP, precursor of 5-HT, (25, 50, 75 and 100 mg/kg, i.p.) were administered, respectively. Results: DOI, at the doses of 1 and 2 mg/kg, significantly decreased penicillin-induced epileptiform activity (p < 0.05). Methysergide, at the doses of 20, 50 and 100 mu M, significantly increased the mean spike frequency of penicillin-induced epileptiform activity (p < 0.05). The doses of 50, 75 and 100 mg/kg of 5-HTP decreased the mean spike frequency of penicillin-induced epileptiform activity (p < 0.05). The mean of amplitude of penicillin-induced epileptiform activity did not significantly change in any of the groups (p > 0.05). Conclusion: The electrophysiological data from the present study suggest that serotonin 5-HT2 receptors have an important role in controlling penicillin-induced epileptiform activity in the rat.