Chemical Constituents of two Sages with Free Radical Scavenging Activity

Demirezer O. L. , Gurbuz P. , Kuruuzum-Uz A., GÜVENALP Z., KAZAZ C., DÖNMEZ A. A.

NATURAL PRODUCT COMMUNICATIONS, vol.7, no.2, pp.187-190, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 2
  • Publication Date: 2012
  • Page Numbers: pp.187-190
  • Keywords: Salvia, Lamiaceae, Free radical scavenging activity, Phenolic acids, Flavonoids, Triterpenes, SALVIA-OFFICINALIS, PHENOLIC-COMPOUNDS, ACID-DERIVATIVES, ANTIOXIDANT, FLAVONOIDS, MILTIORRHIZA


From the aerial parts of Salvia trichoclada Bentham and S. verticillata L. one new and two known phenolic acids, 3-(3',4'-dihydroxyphenyl)-2-hydroxymethyl propionic acid (1), 3-(3',4'-dihydroxyphenyl) lactic acid (2), and rosmarinic acid (3); two flavonoids, apigenin 4'-methyl ether 7-O-glucuronide (4), and luteolin 7-O-beta-glucuronide (5); two lupan type triterpene aglycones, lupeol (6), and 30-hydroxylup-20 (29)-en-3-on (7); an oleanane-type triterpene acid, oleanolic acid (8); and an ursan-type triterpene acid, ursolic acid (9) were isolated. The structures of the compounds were elucidated by spectroscopic analysis. Different extracts of the plants were examined for their free radical scavenging activities by DPPH (2,2-Diphenyl-1-picrylhydrazyl) assay. Some of the polar extracts showed high free radical scavenging activity.