Influence of maternal smoking on neonatal aortic intima-media thickness, serum IGF-I and IGFBP-3 levels

Güneş T., Koklu E., Yıkılmaz A., Ozturk M. A., Akçakuş M., Kurtoglu S., ...More

EUROPEAN JOURNAL OF PEDIATRICS, vol.166, no.10, pp.1039-1044, 2007 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 166 Issue: 10
  • Publication Date: 2007
  • Doi Number: 10.1007/s00431-006-0376-9
  • Journal Name: EUROPEAN JOURNAL OF PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1039-1044
  • Keywords: aortic wall thickness, newborns, maternal nicotine exposure, IGF-I, IGFBP-3, GROWTH-FACTOR-I, CORONARY-HEART-DISEASE, CIGARETTE-SMOKING, RISK-FACTORS, NICOTINE EXPOSURE, FETAL GROWTH, FACTOR AXIS, INSULIN, PREGNANCY, ATHEROSCLEROSIS
  • Erciyes University Affiliated: Yes

Abstract

Epidemiological studies have reported associations between a range of cardiovascular risk factors such as smoking and intima-media thickness (IMT). Some reports indicate that the maternal tobacco smoking causes disturbances of the endocrine status of the foetus. There are several potential mechanisms by which insulin-like growth factor I (IGF-I) could modify atherosclerotic processes either locally or in a systemic manner. The aim of this study was to investigate the influence of maternal smoking on neonatal aortic IMT (aIMT), serum IGF-I and IGF-binding protein-3 (IGFBP-3) levels. Aortic intima-media thickness was measured in 28 neonates whose mothers smoked during the pregnancy and 28 control neonates. Mean and weight-adjusted aIMT were significantly greater in the neonates whose mothers smoked (0.455 +/- 0.009 mm and 0.151 +/- 0.005 mm/kg, respectively) than in controls (0.403 +/- 0.029 mm and 0.118 +/- 0.014 mm/kg, respectively). Birth-weight of newborns whose mothers smoked was less than that of the controls. The decreases in serum IGF-I and IGFBP-3 observed in the infants whose mothers smoked were non-significant. Mean aIMT was negatively associated with birth-weight and IGF-I level. In conclusion, neonates whose mothers smoked have significantly increased aIMT. It might play a role in the pathogenesis of atherosclerosis in adult life.