The research was conducted as an epidemiological study with a before-after interference. Ninety-three women who regularly visited a menopausal clinic in Kayseri and who had begun hormone replacement therapy (HRT) made up the study sample. Seventy-five women were involved in the second step, carried out 18 months after the first interview. It was concluded that 25.3% of the women who began HRT had more menopausal complaints before HRT, while these complaints were generally reduced after the 18 months (p < .05). There was no important change in their quality of life (QOL; p > .05), but there was a positive change seen in emotional reactions (p < .05).