Synthesis of new 4-aza-indoles via acyl azides


Dogan S. D. , DEMİRPOLAT E. , AYCAN M. B. , BALCI M.

TETRAHEDRON, cilt.71, ss.252-258, 2015 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 71 Konu: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.tet.2014.11.057
  • Dergi Adı: TETRAHEDRON
  • Sayfa Sayıları: ss.252-258

Özet

We hereby report the preparation of new azaindole derivatives starting from 2-(2-ethoxy-2-oxoethyl) nicotinic acid. Conversion of a half ester into acyl azide followed by Curtius rearrangement gave the corresponding isocyanate. Trapping of the isocyanate with different nucleophiles produced urea and urethane derivatives. Intramolecular cyclization reactions gave the target compounds. (C) 2014 Elsevier Ltd. All rights reserved.