© 2019 Gazi Eye Foundation. All rights reserved.A 76-years old woman presented to our clinic with bilateral painless decrease in vision for 5 to 6 months. Best corrected visual acuity was 20/640 in the right and 20/500 in the left eye. Slit lamp examination was unremarkable except bilateral pseudophakia. Intraocular pressures were within normal limits. Bilateral severe cystoid macular edema was identified in indirect retina examination and optical coherence tomography (OCT). Patient was prescribed oral capecitabine therapy 10 months ago, which was completed 4 months ago. There was no history of topical or systemic medication other than capecitabine. After treatment with oral acetazolamide and topical steroid and non-steroidal eye drops, best corrected visual acuity was increased to 20/200 in right eye and 20/63 in the left eye. On OCT, it was seen that cystoid macular edema was regressed in the right eye and disappeared in the left eye. This is the first case report about bilateral cystoid macula edema related to capecitabine therapy in the literature.