Association of TNF-alpha 2308 G > A and ACE I/D gene polymorphisms in hemodialysis patients with arteriovenous fistula thrombosis

ŞENER E. F., TAHERİ S., Korkmaz K., ZARARSIZ G., Serhatlioglu F., ÜNAL A., ...More

INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.46, no.7, pp.1419-1425, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 7
  • Publication Date: 2014
  • Doi Number: 10.1007/s11255-013-0580-2
  • Journal Name: INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1419-1425
  • Keywords: Arteriovenous fistula, Cytokine, Hemodialysis, Polymorphism, Thrombosis, ANGIOTENSIN-CONVERTING ENZYME, STAGE RENAL-DISEASE, VASCULAR ACCESS, SYSTEM, RISK, INFLAMMATION, DIALYSIS, PROMOTER, FAILURE
  • Erciyes University Affiliated: Yes

Abstract

Tumor necrosis factor-alpha (TNF - alpha) -308 G > A promoter polymorphism seems to be associated with adverse clinical outcome in hemodialysis patients (HD). Angiotensin-converting enzyme (ACE) gene may be the causative factor contributing to the deterioration of renal functions. The aim of this study was to investigate the relationship between vascular access failure and the genetic polymorphisms of ACE and TNF-alpha gene.