Association of TNF-alpha 2308 G > A and ACE I/D gene polymorphisms in hemodialysis patients with arteriovenous fistula thrombosis


ŞENER E. F. , TAHERİ S. , Korkmaz K., ZARARSIZ G. , Serhatlioglu F. , ÜNAL A. , ...More

INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.46, no.7, pp.1419-1425, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 7
  • Publication Date: 2014
  • Doi Number: 10.1007/s11255-013-0580-2
  • Title of Journal : INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Page Numbers: pp.1419-1425

Abstract

Tumor necrosis factor-alpha (TNF - alpha) -308 G > A promoter polymorphism seems to be associated with adverse clinical outcome in hemodialysis patients (HD). Angiotensin-converting enzyme (ACE) gene may be the causative factor contributing to the deterioration of renal functions. The aim of this study was to investigate the relationship between vascular access failure and the genetic polymorphisms of ACE and TNF-alpha gene.