Genetic diversity of Leishmania tropica: Unexpectedly complex distribution pattern

Charyyeva A., Çetinkaya Ü., Özkan B., Şahin S., Yaprak N., Şahin I., ...Daha Fazla

ACTA TROPICA, cilt.218, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 218
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.actatropica.2021.105888
  • Dergi Adı: ACTA TROPICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Communication Abstracts, EMBASE, Geobase, MEDLINE, Metadex, Veterinary Science Database, Civil Engineering Abstracts
  • Anahtar Kelimeler: Cutaneous leishmaniasis, ITS1, Haplotype diversity, Phylogeography, CUTANEOUS LEISHMANIASIS, VISCERAL LEISHMANIASIS, EPIDEMIOLOGY, DNA
  • Erciyes Üniversitesi Adresli: Evet

Özet

In this study, we characterized a collection of clinical samples obtained from Syrian and Turkish patients with cutaneous leishmaniasis using internal transcribed spacer 1 (ITS1) sequences. All obtained sequences belonged to Leishmania tropica. Combining them with those available from GenBank allowed us performing a broad-scale analysis of genetic diversity for this species. We demonstrated that L. tropica has a complex phylogeographic pattern with some haplotypes being widespread across endemic countries and others restricted to particular regions. We hypothesize that at least some of them may be associated with alternative vectors or animal reservoirs.