Effects of ursodeoxycholic acid therapy on carotid intima media thickness, apolipoprotein A1, apolipoprotein B, and apolipoprotein B/A1 ratio in nonalcoholic steatohepatitis

COSKUN, Banu; Yucesoy, Mehmet; GÜRSOY, ŞEBNEM; BAŞKOL, MEVLÜT; YURCI, Alper; Yagbasan, Ahmet; DOĞAN, SERAP; BAŞKOL, GÜLDEN

doi:10.1097/meg.0000000000000264

Effects of ursodeoxycholic acid therapy on carotid intima media thickness, apolipoprotein A1, apolipoprotein B, and apolipoprotein B/A1 ratio in nonalcoholic steatohepatitis

COSKUN B. D. O., Yucesoy M., GÜRSOY Ş., BAŞKOL M., YURCI A., Yagbasan A., ...Daha Fazla

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, cilt.27, sa.2, ss.142-149, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 27 Sayı: 2
Basım Tarihi: 2015
Doi Numarası: 10.1097/meg.0000000000000264
Dergi Adı: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.142-149
Erciyes Üniversitesi Adresli: Evet

Özet

Background Nonalcoholic steatohepatitis (NASH) is a prevalent liver disease that is increasingly being associated with cardiovascular disease. Ursodeoxycholic acid (UDCA) may have antioxidant and anti-inflammatory activities, and may reduce liver injury in NASH. To date, no studies have assessed the efficacy of UDCA in carotid intima media thickness (CIMT), serum lipids, apolipoprotein A1 (apo A), apolipoprotein B (apo B), and apolipoprotein B/A1 (apo B/A1) ratios in patients with NASH.