Effects of ursodeoxycholic acid therapy on carotid intima media thickness, apolipoprotein A1, apolipoprotein B, and apolipoprotein B/A1 ratio in nonalcoholic steatohepatitis


COSKUN B. D. O. , Yucesoy M. , GÜRSOY Ş. , BAŞKOL M. , YURCI A., Yagbasan A. , ...More

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, vol.27, no.2, pp.142-149, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.1097/meg.0000000000000264
  • Title of Journal : EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
  • Page Numbers: pp.142-149

Abstract

Background Nonalcoholic steatohepatitis (NASH) is a prevalent liver disease that is increasingly being associated with cardiovascular disease. Ursodeoxycholic acid (UDCA) may have antioxidant and anti-inflammatory activities, and may reduce liver injury in NASH. To date, no studies have assessed the efficacy of UDCA in carotid intima media thickness (CIMT), serum lipids, apolipoprotein A1 (apo A), apolipoprotein B (apo B), and apolipoprotein B/A1 (apo B/A1) ratios in patients with NASH.