The Release of Doxorubicin's Active Ingredient from the Hydrogels with Poly (HEMA/Acrylamide/Itaconic acid) and Their Biological Function


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KARİPER I. A.

INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, vol.51, no.3, pp.401-406, 2017 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.5530/ijper.51.3.67
  • Title of Journal : INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
  • Page Numbers: pp.401-406

Abstract

In this study, Poly (HEMA/Acrylamide/ Itaconic acid) (HAI) polymer was synthesized for using in the release of Doxorubicin drug. Poly (HEMA/acrylamide/ Itaconic acid) (HAI) hydrogel was prepared by a radical addition reaction in aqueous media formed by HEMA, acrylamide, Itaconic acid, in the presence of TEMED (N, N, N', N'-tetramethylenediamine). The characterization of the polymer was performed by FTIR analysis. At the same time, swelling and drug absorption capabilities of the polymers were analyzed. It has been observed that the entire drug, which was added to the solution with 0.1 mg of polymer, was absorbed in around 25 hours. This measurement showed that the absorption of this polymer is quite high compared to many polymers in the literature. Moreover, this polymer showed 80% swelling at 1000 minutes. In the light of these results, it has been concluded that this new polymer is very suitable for the release of Doxorubicin drug.