Antimicrobial peptides (AMPs): A promising class of antimicrobial compounds


Erdem Buyukkiraz M., Kesmen Z.

JOURNAL OF APPLIED MICROBIOLOGY, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Publication Date: 2021
  • Doi Number: 10.1111/jam.15314
  • Title of Journal : JOURNAL OF APPLIED MICROBIOLOGY
  • Keywords: antibacterial, antimicrobial peptides, antiviral, applications of AMPs, mechanism of action, origins of AMPs, PLANT-PATHOGENIC BACTERIA, CYCLIC CYSTINE LADDER, ANTIBACTERIAL PEPTIDE, MEMBRANE INTERACTIONS, TRANSGENIC TOBACCO, PICHIA-PASTORIS, PHYTOPATHOGENIC BACTERIA, DIETARY SUPPLEMENTATION, ENHANCES RESISTANCE, INHIBITORY-ACTIVITY

Abstract

Antimicrobial peptides (AMPs) are compounds, which have inhibitory activity against microorganisms. In the last decades, AMPs have become powerful alternative agents that have met the need for novel anti-infectives to overcome increasing antibiotic resistance problems. Moreover, recent epidemics and pandemics are increasing the popularity of AMPs, due to the urgent necessity for effective antimicrobial agents in combating the new emergence of microbial diseases. AMPs inhibit a wide range of microorganisms through diverse and special mechanisms by targeting mainly cell membranes or specific intracellular components. In addition to extraction from natural sources, AMPs are produced in various hosts using recombinant methods. More recently, the synthetic analogues of AMPs, designed with some modifications, are predicted to overcome the limitations of stability, toxicity and activity associated with natural AMPs. AMPs have potential applications as antimicrobial agents in food, agriculture, environment, animal husbandry and pharmaceutical industries. In this review, we have provided an overview of the structure, classification and mechanism of action of AMPs, as well as discussed opportunities for their current and potential applications.