Research Information System
Anti-Cancer Agents in Medicinal Chemistry, vol.23, no.20, pp.2189-2199, 2023 (SCI-Expanded)
Background: Green synthesis is an efficient and eco-friendly method that has been used frequently in silver nanoparticle production in recent years. This method facilitates the production of nanoparticles using various organ-isms, such as plants, and is also cheaper and easier to apply than the other techniques. Aims: This study aims to find possible mechanisms and pharmacological effects of cubic silver nanoparticles (AgNPs). Objectives: This study characterizes cubic AgNPs and describes in detail their anticancer, antimicrobial, and anti-Trichomonas vaginalis abilities. Methods: Silver nanoparticles were produced by green synthesis using Juglans regia (walnut) leaf aqueous extract. We validated the formation of AgNPs by UV-vis spectroscopy, FTIR analysis, and SEM micrographs. To determine the pharmacological effects of the AgNPs, we conducted anti-cancer, anti-bacterial, and anti-parasitic activity experiments. Results: Cytotoxicity data revealed that AgNPs have cellular inhibitory properties on cancerous MCF7 (breast), HeLa (cervix), C6 (glioma), and HT29 (colorectal) cell lines. Similar results are also obtained with anti-bacterial and anti-Trichomonas vaginalis activity experiments. At certain concentrations, AgNPs displayed stronger anti-bacterial activities than the sulbactam/cefoperazone antibiotic combination in five bacteria species. Furthermore, the 12-h AgNPs treatment exhibited satisfactory anti-Trichomonas vaginalis activity similar to the FDA-approved metronidazole. Conclusion: Consequently, AgNPs produced by the green synthesis method by Juglans regia leaves showed remarka-ble anti-carcinogenic, anti-bacterial, and anti-trichomonas vaginalis activities. We propose the potential usefulness of green synthesized AgNPs as therapeutics.