Protective effect of magnesium supplementation on experimental 3-methyl cholantrene-induced fibrosarcoma and changes in tissue magnesium distribution during carcinogenesis in rats


PATIROGLU T., SAHIN G., Kontas O. , UZUM K. , SARAYMEN R.

BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.56, ss.179-185, 1997 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 56 Konu: 2
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1007/bf02785391
  • Dergi Adı: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Sayfa Sayısı: ss.179-185

Özet

In this study, we wanted to examine the effect of magnesium (Mg2+) supplementation on the experimental 3-methyl cholantrene (3-MC)-induced fibrosarcoma and alterations in (Mg2+) distribution in several tissues of the rats, during carcinogenesis. It was determined that serum and tissue (Mg2+) levels of the rats in (Mg2+)-supplemented diet group were higher than those of the rats in the (Mg2+)-nonsupplemented and control groups. The mean time of fibrosarcoma development for (Mg2+)-supplemented group was longer than (Mg2+)-nonsupplemented group (p < 0.05). Symptoms of hypermagnesemia were not observed in any of the rats. These results suggests that dietary (Mg2+) supplementation may have a partial anticarcinogenic effect on experimental 3-MC-induced fibrosarcoma by prolongation of the latent period of carcinogenesis.