Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappa B p65-associated histone acetyltransferase activity
CLINICAL AND EXPERIMENTAL ALLERGY, cilt.38, sa.5, ss.805-811, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 38 Sayı: 5
- Basım Tarihi: 2008
- Doi Numarası: 10.1111/j.1365-2222.2008.02963.x
- Dergi Adı: CLINICAL AND EXPERIMENTAL ALLERGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.805-811
- Erciyes Üniversitesi Adresli: Hayır
Özet
Background Montelukast is a potent cysteinyl leukotriene-1 receptor antagonist possessing some anti-inflammatory effects although the molecular mechanism of these anti-inflammatory effects is unknown. In this study, we aimed to investigate the effect of montelukast on nuclear factor (NF)-kappa B-associated histone acetylation activity in phorbol myristate acetate (PMA)-differentiated U937 cells.