Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappa B p65-associated histone acetyltransferase activity

TAHAN F., Jazrawi E., Moodley T., Rovati G. E., Adcock I. M.

CLINICAL AND EXPERIMENTAL ALLERGY, vol.38, no.5, pp.805-811, 2008 (SCI-Expanded) identifier


Background Montelukast is a potent cysteinyl leukotriene-1 receptor antagonist possessing some anti-inflammatory effects although the molecular mechanism of these anti-inflammatory effects is unknown. In this study, we aimed to investigate the effect of montelukast on nuclear factor (NF)-kappa B-associated histone acetylation activity in phorbol myristate acetate (PMA)-differentiated U937 cells.