Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappa B p65-associated histone acetyltransferase activity

TAHAN, FULYA; Jazrawi, E.; Moodley, T.; Rovati, G.; Adcock, I.

doi:10.1111/j.1365-2222.2008.02963.x

Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappa B p65-associated histone acetyltransferase activity

Atıf İçin Kopyala

TAHAN F., Jazrawi E., Moodley T., Rovati G. E., Adcock I. M.

CLINICAL AND EXPERIMENTAL ALLERGY, cilt.38, sa.5, ss.805-811, 2008 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 38 Sayı: 5
Basım Tarihi: 2008
Doi Numarası: 10.1111/j.1365-2222.2008.02963.x
Dergi Adı: CLINICAL AND EXPERIMENTAL ALLERGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.805-811
Erciyes Üniversitesi Adresli: Evet

Özet

Background Montelukast is a potent cysteinyl leukotriene-1 receptor antagonist possessing some anti-inflammatory effects although the molecular mechanism of these anti-inflammatory effects is unknown. In this study, we aimed to investigate the effect of montelukast on nuclear factor (NF)-kappa B-associated histone acetylation activity in phorbol myristate acetate (PMA)-differentiated U937 cells.