Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappa B p65-associated histone acetyltransferase activity


TAHAN F. , Jazrawi E., Moodley T., Rovati G. E. , Adcock I. M.

CLINICAL AND EXPERIMENTAL ALLERGY, vol.38, no.5, pp.805-811, 2008 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 5
  • Publication Date: 2008
  • Doi Number: 10.1111/j.1365-2222.2008.02963.x
  • Title of Journal : CLINICAL AND EXPERIMENTAL ALLERGY
  • Page Numbers: pp.805-811

Abstract

Background Montelukast is a potent cysteinyl leukotriene-1 receptor antagonist possessing some anti-inflammatory effects although the molecular mechanism of these anti-inflammatory effects is unknown. In this study, we aimed to investigate the effect of montelukast on nuclear factor (NF)-kappa B-associated histone acetylation activity in phorbol myristate acetate (PMA)-differentiated U937 cells.