Etiological Factors of Opsoclonus Myoclonus Ataxia Syndrome: A Single Center Experience with Eight Children
TRENDS IN PEDIATRICS, vol.3, no.4, pp.120-125, 2022 (ESCI, TRDizin)
- Publication Type: Article / Article
- Volume: 3 Issue: 4
- Publication Date: 2022
- Doi Number: 10.4274/tp.2022.29292
- Journal Name: TRENDS IN PEDIATRICS
- Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
- Page Numbers: pp.120-125
- Keywords: OMAS, opsoclonus, myoclonus, ataxia, neuroblastoma
- Erciyes University Affiliated: Yes
Abstract
Objective: Opsoclonus myoclonus ataxia syndrome (OMAS) is a rare neurological disorder characterized by acute/subacute onset multi -directional chaotic eye movements, accompanied by myoclonus and cerebellar ataxia; as well as sleep disturbance, cognitive dysfunction, and behavioral disturbance can be observed. Methods: We examined the information of eight patients (four females, four males) who applied to the hospital with OMAS between 2013 and 2020 from the medical records of the patients. Results: The median age of onset of the initial symptoms was 17.5 months (8-30 months). The most common initial complaints were abnormal eye movement and gait unsteadiness, respectively. Paraneoplastic OMAS was observed in three patients (37.5%), whereas idiopathic and infection -related OMAS was detected in three, and two patients, respectively. Conclusion: We emphasize that all symptoms of OMAS may not occur simultaneously, therefore comprehensive systemic investigations, and close observation should be made in patients with suspected OMAS.