Research Information System
7TH INTERNATIONAL ACHARAKA CONGRESS ON MEDICINE, NURSING, MIDWIFERY, AND HEALTH SCIENCES, İstanbul, Turkey, 20 - 22 June 2024, pp.439-440
Aging represents a complex process influenced by genetic and environmental factors that can
lead to the loss of certain body functions. Skin, the largest organ in the human body regarding
surface area and mass, is a barrier between the body and the external environment. The aging
of the skin can lead to structural and functional disorders. Changes resulting from
environmental factors occur through epigenetic mechanisms and modifications, which affect
gene expression levels without altering the DNA base sequence and can be inherited by
subsequent generations.
DNA methylation is one of the significant epigenetic mechanisms that involves adding a methyl
group to the 5th atom of cytosine in the DNA base sequence by DNA methyltransferases
(DNMTs). DNMT2, a member of the DNMT family, was initially thought to be an enzyme
involved in DNA methylation. However, advancements in this field have shown that DNMT2
adds a methyl group to tRNA, which is involved in protein translation, using the DNMT enzyme
mechanism. This methylation increases the stability of tRNA, thereby contributing to protein
synthesis. Dnmt2 is related to tRNA functions and the physiological functions of living