This study presents time-dependent transmutations of high-level waste (HLW) including minor actinides (MAs) and long-lived fission products (LLFPs) in the fusion-driven transmuter (FDT) that is optimized in terms of the neutronic performance per fusion neutron in our previous study. Its blanket has two different transmutation zones (MA transmutation zone, TZ(MA), and LLFP transmutation zone, TZ(FP)), located separately from each other. High burn-up pressured water reactor (PWR)-mixed oxide (MOX) spent fuel is used as HLW. The time-dependent transmutation analyses have been performed for an operation period (OP) of up to 10 years by 75% plant factor (eta) under a first-wall neutron load (P) of 5 MW/m(2). The effective half-lives of the MA and LLFP nuclides can be shortened significantly in the considered FDT while substantial electricity is produced in situ along the OP.