Micronucleus evaluation in mitogen-stimulated lymphocytes of narrow-band (311 nm TL01) UVB-treated patients
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, cilt.20, sa.2, ss.81-85, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 20 Sayı: 2
- Basım Tarihi: 2004
- Doi Numarası: 10.1111/j.1600-0781.2004.00086.x
- Dergi Adı: PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.81-85
- Anahtar Kelimeler: micronucleus, narrow-band UVB
- Erciyes Üniversitesi Adresli: Evet
Özet
Background: Narrow-band UVB (311 nm) lamps (TL01) are being increasingly used for phototherapy of psoriasis and other dermatoses, for their excellent effect compared with broad-band UVB sources and photochemotherapy. It is acknowledged that the TL01 lamp is probably two to three times more carcinogenic per minimum erythema dose than broad-band UVB, but the cumulative dose is considerably less than broadband UVB sources. Micronucleus (MN) test is used to detect both clastogenic (breaking) and aneugenic (abnormal segregation) effect of physical/chemical agents on chromosomes. The aim of this study is to evaluate MN frequencies in mitogen-stimulated lymphocytes of narrow-band UVB-treated patients.