Micronucleus evaluation in mitogen-stimulated lymphocytes of narrow-band (311 nm TL01) UVB-treated patients

Ferahbas, Ayten; Donmez-Altuntas, HAMİYET; hamurcu, ZÜHAL; aktaş, e; utas, Serap

doi:10.1111/j.1600-0781.2004.00086.x

Micronucleus evaluation in mitogen-stimulated lymphocytes of narrow-band (311 nm TL01) UVB-treated patients

Atıf İçin Kopyala

Ferahbas A., Donmez-Altuntas H., hamurcu z., aktaş e., utas s.

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, cilt.20, sa.2, ss.81-85, 2004 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 20 Sayı: 2
Basım Tarihi: 2004
Doi Numarası: 10.1111/j.1600-0781.2004.00086.x
Dergi Adı: PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.81-85
Erciyes Üniversitesi Adresli: Evet

Özet

Background: Narrow-band UVB (311 nm) lamps (TL01) are being increasingly used for phototherapy of psoriasis and other dermatoses, for their excellent effect compared with broad-band UVB sources and photochemotherapy. It is acknowledged that the TL01 lamp is probably two to three times more carcinogenic per minimum erythema dose than broad-band UVB, but the cumulative dose is considerably less than broadband UVB sources. Micronucleus (MN) test is used to detect both clastogenic (breaking) and aneugenic (abnormal segregation) effect of physical/chemical agents on chromosomes. The aim of this study is to evaluate MN frequencies in mitogen-stimulated lymphocytes of narrow-band UVB-treated patients.