Micronucleus evaluation in mitogen-stimulated lymphocytes of narrow-band (311 nm TL01) UVB-treated patients


Ferahbas A. , Donmez-Altuntas H. , hamurcu z. , aktaş e., utas s.

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, vol.20, no.2, pp.81-85, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 2
  • Publication Date: 2004
  • Doi Number: 10.1111/j.1600-0781.2004.00086.x
  • Title of Journal : PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
  • Page Numbers: pp.81-85

Abstract

Background: Narrow-band UVB (311 nm) lamps (TL01) are being increasingly used for phototherapy of psoriasis and other dermatoses, for their excellent effect compared with broad-band UVB sources and photochemotherapy. It is acknowledged that the TL01 lamp is probably two to three times more carcinogenic per minimum erythema dose than broad-band UVB, but the cumulative dose is considerably less than broadband UVB sources. Micronucleus (MN) test is used to detect both clastogenic (breaking) and aneugenic (abnormal segregation) effect of physical/chemical agents on chromosomes. The aim of this study is to evaluate MN frequencies in mitogen-stimulated lymphocytes of narrow-band UVB-treated patients.