Higher NORs-expression in lymphocyte of trisomy 21 babies/children: In vivo evaluation

Imamoglu N. N. , Demirtas H., Donmez-Altuntas H. , Ilten A.

MICRON, vol.36, no.6, pp.503-507, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 36 Issue: 6
  • Publication Date: 2005
  • Doi Number: 10.1016/j.micron.2005.05.002
  • Title of Journal : MICRON
  • Page Numbers: pp.503-507


Extra chromosome 21 of Down syndrome (DS) or trisomy 21 patients contains an average of 40 extra copies of rRNA genes and the in vivo regulation of these genes is not known. The objective of this work is to compare the NORs expression in interphase nuclei in non-stimulated lymphocytes of DS patients and healthy controls.