Higher NORs-expression in lymphocyte of trisomy 21 babies/children: In vivo evaluation


Imamoglu N. N., Demirtas H., Donmez-Altuntas H., Ilten A.

MICRON, vol.36, no.6, pp.503-507, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 36 Issue: 6
  • Publication Date: 2005
  • Doi Number: 10.1016/j.micron.2005.05.002
  • Journal Name: MICRON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.503-507
  • Keywords: Down syndrome, trisomy 21, in vivo AgNORs, DOWN-SYNDROME BRAIN, PROTEIN-LEVELS, CHROMOSOME-21, AGNOR, REGIONS
  • Erciyes University Affiliated: Yes

Abstract

Extra chromosome 21 of Down syndrome (DS) or trisomy 21 patients contains an average of 40 extra copies of rRNA genes and the in vivo regulation of these genes is not known. The objective of this work is to compare the NORs expression in interphase nuclei in non-stimulated lymphocytes of DS patients and healthy controls.