Metabolic risk factors and the role of prophylaxis in pediatric urolithiasis


Untan I., Untan S., Tosun H., DEMİRCİ D.

JOURNAL OF PEDIATRIC UROLOGY, vol.17, no.2, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.1016/j.jpurol.2020.12.003
  • Title of Journal : JOURNAL OF PEDIATRIC UROLOGY

Abstract

Suppose that the recurrence in pediatric urolithiasis has a close relationship with metabolic abnormal-ities and is affected by residual burden and pro-phylaxis. If so, the recurrence rates could be reduced with effective surgery and appropriate prophylaxis. Here we retrospectively evaluate the metabolic risk factors data of 148 children who were operated on between January 2005 and March 2013 due to kidney stones. All patients underwent percutaneous nephrolithotomy (PCNL), and all were children. Thirteen children had a history of surgery performed to treat urological anomalies. Twenty-four-hour urine analysis, the residual status of sur-gery, BMI levels, and the number of metabolic ab-normalities were noted. Only 18 (15%) of 122 patients without residual stones after PCNL had recurrence at follow-up whereas; nine (26%) of 26 patients with residual stones developed recurrence (p = 0.017). Recurrence was observed in 14 (16%) of 89 patients with a metabolic abnormality, and 13 (30%) of 44 patients with two or more metabolic abnormalities had recurrence at follow-up (p = 0.024). Those patients with no metabolic ab-normalities did not develop recurrence. Stone recurrence was seen in six (8%) of 78 children who were given metabolic prophylaxis, compared to 21 (30%) of 70 patients who did not receive metabolic prophylaxis (p = 0.02). No stone recurrence was seen in nine children who were given Shohl?s, whereas four (67%) of six patients who did not take Shohl?s had recurrence (p = 0.022). Complete removal of stones by a suitable surgical method is essential to avoid recurrences. Detailed clinical and laboratory evaluations should be performed in chil-dren with urolithiasis. Appropriate specific prophy-lactic treatment (e.g., potassium citrate and Shohl?s) and non-specific prophylactic treatment (e.g., avoiding animal proteins, salt, simple sugars, and increased water intake) should be given to prevent reformation of stones in patients with pe-diatric urolithiasis.