Synthesis and potent antistaphylococcal activity of some new 2-[4-(3,4-dimethoxyphenoxy) phenyl]-1, N-disubstituted-1H-benzimidazole-5-carboxamidines


Puskullu M. O. , Yildiz S., Duydu Y., Ustundag A., Goker H.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.30, ss.173-179, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 30 Konu: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3109/14756366.2014.899593
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Sayfa Sayıları: ss.173-179

Özet

A series of new 2-[4-(3,4-dimethoxyphenoxy) phenyl]-1, N-disubstituted-1H-benzimidazole-5carboxamidines (23-33) have been synthesized and evaluated for their potential antistaphylococcal activity. Cytotoxic effects of the compounds were investigated by the neutral red uptake (NRU) cytotoxicity test. Most of the compounds exhibited good MICs values against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). Compound 28 with N-cyclohexylcarboxamidine group at the 5-position was found to be the most potent agent, with the MIC value of 3.12 mu g/mL.