Renal effects of long-term leptin infusion and preventive role of losartan treatment in rats

Gunduz Z., Dursun N., Akgun H., Ozturk F., OKUR H., Koc N.

REGULATORY PEPTIDES, vol.132, pp.59-66, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 132
  • Publication Date: 2005
  • Doi Number: 10.1016/j.regpep.2005.09.017
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.59-66
  • Erciyes University Affiliated: Yes


Background: Leptin has direct and indirect effects on renal pathophysiological characteristics. In the present study, the effects of long-term leptin infusion on the renal hemodynamics, renal excretory functions, and the expression of transforming growth factor-beta (TGF-beta), plasma endothelin-1 (ET-1) levels, and preventive effects of the angiotensin II type I receptor antagonist, losartan, on these renal changes were evaluated.