Effect of obesity and morbid obesity on the growth hormone (GH) secretion elicited by the combined GHRH+GHRP-6 test

Kelestimur F. , Popovic V., Leal A., Van Dam P. S. , Torres E., Perez L. F. M. , ...Daha Fazla

CLINICAL ENDOCRINOLOGY, cilt.64, sa.6, ss.667-671, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 64 Konu: 6
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1111/j.1365-2265.2006.02525.x
  • Sayfa Sayıları: ss.667-671


Objective Obesity is characterized by low basal levels of growth hormone (GH) and impeded GH release. However, the main problem arises in the diagnosis of GH deficiency in adults, as all accepted cut-offs in the diagnostic tests of GH reserve are no longer valid in obese subjects. In this work, the role of obesity in the GH response elicited by the GHRH + GHRP-6 test was assessed in a large population of obese and nonobese subjects.