The Effects of Galantamine Hydrobromide Treatment on Dehydroepiandrosterone Sulfate and Cortisol Levels in Patients with Chronic Fatigue Syndrome


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Turan T., Izgi H. B., OZSOY S., TANRIVERDİ F., BAŞTÜRK M., ASDEMİR A., ...More

PSYCHIATRY INVESTIGATION, vol.6, no.3, pp.204-210, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 3
  • Publication Date: 2009
  • Doi Number: 10.4306/pi.2009.6.3.204
  • Journal Name: PSYCHIATRY INVESTIGATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.204-210
  • Erciyes University Affiliated: Yes

Abstract

Objective Mental fatigue, cognitive disorders, and sleep disturbances seen in chronic fatigue syndrome (CPS) may be attributed to cholinergic deficit. A functional deficiency of cholinergic neurotransmission may cause the hypothalamic-pituitary-adrenal axis hypoactivity seen in CPS. Therefore, we investigated the alterations in stress hormones such as cortisol and dehydroepiandrosterone sulfate (DHEAS) in CPS patients before and after 4-week administration of galantamine hydrobromide, a selective acetylcholinesterase inhibitor, and aimed to investigate whether there are any relationships between the probable hormonal changes and cholinergic treatment.