The Effects of Galantamine Hydrobromide Treatment on Dehydroepiandrosterone Sulfate and Cortisol Levels in Patients with Chronic Fatigue Syndrome

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Turan T. , Izgi H. B. , OZSOY S. , TANRIVERDİ F. , BAŞTÜRK M. , ASDEMİR A. , et al.

PSYCHIATRY INVESTIGATION, cilt.6, ss.204-210, 2009 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 6 Konu: 3
  • Basım Tarihi: 2009
  • Doi Numarası: 10.4306/pi.2009.6.3.204
  • Sayfa Sayısı: ss.204-210


Objective Mental fatigue, cognitive disorders, and sleep disturbances seen in chronic fatigue syndrome (CPS) may be attributed to cholinergic deficit. A functional deficiency of cholinergic neurotransmission may cause the hypothalamic-pituitary-adrenal axis hypoactivity seen in CPS. Therefore, we investigated the alterations in stress hormones such as cortisol and dehydroepiandrosterone sulfate (DHEAS) in CPS patients before and after 4-week administration of galantamine hydrobromide, a selective acetylcholinesterase inhibitor, and aimed to investigate whether there are any relationships between the probable hormonal changes and cholinergic treatment.