Investigation of the cytotoxic potential of Crocus chrysanthus (Herb.) Herb.


Pasayeva L. , Telkırat H. Ş. , Karaboğa Arslan A. K. , Tugay O.

4th NPCPT , Kayseri, Turkey, 18 - 19 December 2021, pp.34

  • Publication Type: Conference Paper / Summary Text
  • City: Kayseri
  • Country: Turkey
  • Page Numbers: pp.34

Abstract

It is known some difficulties of synthetic drugs use in cancer therapy because of side effects and interactions nowadays. Crocus L. is one of the most diverse genera of Iridaceae family. The genus comprises of 132 taxa, of which 108 are endemic to Turkey. One of them is Crocus chrysanthus. In this study, the cytotoxic effect of methanol extract and petroleum ether, ethyl acetate, n-buthanol and water sub-extracts from C. chrysanthus flowers were evaluated on MCF-7 and HepG2 cell lines. In a result, it was shown that methanol extract and ethyl acetate sub-extract were cytotoxic both cancer cell lines. But further studies will be needed to investigate the mechanism of action for the cytotoxic effects of the extracts.