Chemical profile, antioxidant properties and enzyme inhibitory effects of the root extracts of selected Potentilla species

Uysal S., Zengin G., Mahomoodally M. F., Yilmaz M. A., Aktumsek A.

SOUTH AFRICAN JOURNAL OF BOTANY, vol.120, pp.124-128, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 120
  • Publication Date: 2019
  • Doi Number: 10.1016/j.sajb.2018.01.014
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.124-128
  • Erciyes University Affiliated: Yes


Plants from the genus Potentilla have been traditionally used for therapeutic purposes in Turkey. Methanol root extracts from four selected Potentilla species (P. anatolica, P. argentea, P. recta, and P. reptans) were probed for their chemical composition, antioxidant properties (DPPH, ABTS, FRAP, CUPRAC, phosphomolybdenum, and metal chelating activity), and enzyme (acetylcholinesterase (AChE), butyrylcholinesterase (BChE), alpha-amylase, alpha-glucosidase, and tyrosinase) inhibition effects. In addition, the total phenolic, flavonoid, saponin, and triterpenoid content of the extracts were determined. Ultra-high performance liquid chromatography (UHPLC)-electrospray ionization (ESI)-tandemmass spectrometry (MS/MS) analysis revealed that the main phenolic components in extracts were coumarin, hesperidin, p-coumaric acid, gallic acid, and rutin. P. recta and P. reptans showed the highest total phenolic, saponin, and triterpenoid content. The root extracts showed significant antioxidant properties and depicted significant inhibitory effects against AChE, BChE, alpha-amylase, alpha-glucosidase, and tyrosinase. In conclusion, root extracts of Potentilla may be considered as new natural antioxidants and key enzyme inhibitors that can be exploited as bioproducts for pharmaceutical industries. (c) 2018 SAAB. Published by Elsevier B.V. All rights reserved.