Evaluation of bioreductive activation of anticancer drugs idarubicin and mitomycin C by NADH-cytochrome b5 reductase and cytochrome P450 2B4

Celik H., ARINÇ E.

XENOBIOTICA, vol.43, no.3, pp.263-275, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.3109/00498254.2012.715212
  • Journal Name: XENOBIOTICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.263-275
  • Erciyes University Affiliated: Yes

Abstract

1. This study attempted to investigate the ability of microsomal NADH-cytochrome b5 reductase and cytochrome P450 2B4 to reductively activate idarubicin and mitomycin C.