CAN THE CLASSICAL EUCHROMATIC VARIANTS OF 9q12/qh+ CAUSE RECURRENT ABORTIONS?


Duadar M., Caglaian A. O. , SAATÇİ Ç. , Batukan C., BAŞBUĞ M. , ÖZKUL Y.

GENETIC COUNSELING, vol.19, no.3, pp.281-286, 2008 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 3
  • Publication Date: 2008
  • Title of Journal : GENETIC COUNSELING
  • Page Numbers: pp.281-286

Abstract

Can the classical euchromatic variants of 9q12/qh+ cause recurrent abortions?: Various heteromorphisms of the 9q heterochromatic area have been reported, and the 9q12/qh varient has been postulated to be more prevalent than initially perceived. Of note is that all probands are clinically normal. This paper documents two cases with a G-band within the 9q12h region and recurrent miscarriages. Patient 1 is a 22-year-old woman with a history of 2 miscarriages. Patient 2 is a 19-year-old woman with a history of 3 miscarriages. Chromosome analysis of the patients showed 46,XX,9q12h+. Thus, the existence of a G+ band in 9qh may not be a normal variant in humans. We suggest IVF and preimplantation genetic diagnosis in such patients.