In vitro pharmacological screening of antioxidant, cytotoxic and enzyme inhibitory activities of Citrus aurantifolia Linn. Dried fruit extract

Şeker K., Yücel A., Çakır A., Köngül Ş.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH, vol.31, no.8, pp.991-1000, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 8
  • Publication Date: 2021
  • Doi Number: 10.1080/09603123.2020.1714558
  • Journal Name: INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, CINAHL, Educational research abstracts (ERA), EMBASE, Environment Index, Food Science & Technology Abstracts, Geobase, MEDLINE, Pollution Abstracts, Veterinary Science Database
  • Page Numbers: pp.991-1000
  • Keywords: Lime Basra, citrus aurantifolia, antioxidant, cytotoxicity, alpha-amylase, ESSENTIAL OIL, PEEL EXTRACT, APOPTOSIS, SINENSIS, HYSTRIX, CELLS, JUICE, DC.
  • Erciyes University Affiliated: Yes

Abstract

The Lime Basra (Citrus aurantifolia Linn., Rutaceae) plant also known as dried lime, and Limoo Omani, is used both as a spice in meals and as an herbal tea in the treatment of some diseases in the Middle East. It was aimed to determine the biological activity screening of the 70% methanol, ethanol extracts and infusion which were prepared from dried fruits. 1,1-diphenyl-2-picrylhydrazyl (DPPHBLACK CIRCLE) and 2,2MODIFIER LETTER PRIME-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS+(BLACK CIRCLE)) radical scavenging activities, ferric reducing activity, cytotoxicity on A 549, MCF 7 and L929 cell lines and alpha-amylase inhibitory effects were determined. According to the results, 70% methanol extract was more active in antioxidant activity tests and ethanol extract was more active in cytotoxicity tests. Interestingly both 70% methanol and ethanol extracts were found to have potent hypoglycemic activity. The present findings shed light on the fact that it is important to research and scientifically evaluate plants with traditional medicinal use.